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Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed

Chemotherapeutic agents modify intracellular signaling that culminates in inhibition of Bcl-2 family members and initiates apoptosis. Inhibition of the Extracellular signal-Regulated Kinase by PD98059 dramatically accelerates vinblastine-mediated apoptosis in ML-1 leukemia with cells dying in 4 h fr...

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Bibliografiske detaljer
Main Authors: Salerni, Bethany L, Bates, Darcy J., Albershardt, Tina C., Lowrey, Christopher H., Eastman, Alan
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852489/
https://ncbi.nlm.nih.gov/pubmed/20371726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0028
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