Inhibition of the Proprotein Convertases Represses the Invasiveness of Human Primary Melanoma Cells with Altered p53, CDKN2A and N-Ras Genes

BACKGROUND: Altered tumor suppressor p53 and/or CDKN2A as well as Ras genes are frequently found in primary and metastatic melanomas. These alterations were found to be responsible for acquisition of invasive and metastatic potential through their defective regulatory control of metalloproteinases a...

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Detalhes bibliográficos
Main Authors: Lalou, Claude, Scamuffa, Nathalie, Mourah, Samia, Plassa, Francois, Podgorniak, Marie-Pierre, Soufir, Nadem, Dumaz, Nicolas, Calvo, Fabien, Basset-Seguin, Nicole, Khatib, Abdel-Majid
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852400/
https://ncbi.nlm.nih.gov/pubmed/20404912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009992
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