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Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells

The proprotein convertases (PCs) are implicated in the activation of various precursor proteins that play an important role in tumor cell metastasis. Here, we report their involvement in the regulation of the metastatic potential of colorectal tumor cells. PC function in the human and murine colon c...

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Main Authors: Scamuffa, Nathalie, Siegfried, Geraldine, Bontemps, Yannick, Ma, Liming, Basak, Ajoy, Cherel, Ghislaine, Calvo, Fabien, Seidah, Nabil G., Khatib, Abdel-Majid
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2117762/
https://ncbi.nlm.nih.gov/pubmed/18064302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32040
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