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c-Abl mediates endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 and by disruption of actin

Inhibition of integrins αvβ3 and αvβ5 in human brain microvascular endothelial cells (HBMECs) by the function-blocking peptide RGDfV induces loss of spreading on vitronectin, cell detachment, and apoptosis. We demonstrate that cell detachment is not required for apoptosis because plating on bovine s...

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Autors principals: Xu, Jingying, Millard, Melissa, Ren, Xiuhai, Cox, Orla T., Erdreich-Epstein, Anat
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852370/
https://ncbi.nlm.nih.gov/pubmed/20124512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-223776
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