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RNA Mediated Neurodegeneration in Repeat Expansion Disorders
Most neurodegenerative disorders are thought to result primarily from the accumulation of misfolded proteins which interfere with protein homeostasis in neurons. For a subset of diseases, however, non-coding regions of RNAs assume a primary toxic gain-of-function leading to degeneration in many tiss...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2852186/ https://ncbi.nlm.nih.gov/pubmed/20373340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21948 |
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