ATP-gated P2X(3) receptors constitute a positive autocrine signal for insulin release in the human pancreatic β cell

Extracellular ATP has been proposed as a paracrine signal in rodent islets, but it is unclear what role ATP plays in human islets. We now show the presence of an ATP signaling pathway that enhances the human β cell's sensitivity and responsiveness to glucose fluctuations. By using in situ hybri...

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Hauptverfasser: Jacques-Silva, M. Caroline, Correa-Medina, Mayrin, Cabrera, Over, Rodriguez-Diaz, Rayner, Makeeva, Natalia, Fachado, Alberto, Diez, Juan, Berman, Dora M., Kenyon, Norma S., Ricordi, Camillo, Pileggi, Antonello, Molano, R. Damaris, Berggren, Per-Olof, Caicedo, Alejandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851966/
https://ncbi.nlm.nih.gov/pubmed/20308565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908935107
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