Glutamate Is a Positive Autocrine Signal for Glucagon Release

An important feature of glucose homeostasis is the effective release of glucagon from the pancreatic α cell. The molecular mechanisms regulating glucagon secretion are still poorly understood. We now demonstrate that human α cells express ionotropic glutamate receptors (iGluRs) that are essential fo...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Cabrera, Over, Jacques-Silva, M. Caroline, Speier, Stephan, Yang, Shao-Nian, Köhler, Martin, Fachado, Alberto, Vieira, Elaine, Zierath, Juleen R., Kibbey, Richard, Berman, Dora M., Kenyon, Norma S., Ricordi, Camillo, Caicedo, Alejandro, Berggren, Per-Olof
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396785/
https://ncbi.nlm.nih.gov/pubmed/18522835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.03.004
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