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Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis

Piccolo and bassoon are highly homologous multidomain proteins of the presynaptic cytomatrix whose function is unclear. Here, we generated piccolo knockin/knockout mice that either contain wild-type levels of mutant piccolo unable to bind Ca(2+) (knockin), ∼60% decreased levels of piccolo that is C-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mukherjee, Konark, Yang, Xiaofei, Gerber, Stefan H., Kwon, Hyung-Bae, Ho, Angela, Castillo, Pablo E., Liu, Xinran, Südhof, Thomas C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851964/
https://ncbi.nlm.nih.gov/pubmed/20332206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002307107
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