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Cis lethal genetic interactions attenuate and alter p53 tumorigenesis
Rpa1, an essential gene involved in DNA replication and genome maintenance, is syntenic and linked to Trp53 in mice and humans. To study the genetic interaction between Rpa1 and Trp53 in tumorigenesis, we generated compound Rpa1(L230P/+); Trp53(+/−) mutant mice with the mutant alleles in either tran...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851751/ https://ncbi.nlm.nih.gov/pubmed/20212136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001223107 |
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