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Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

It has been suggested that cGMP kinase I (cGKI) dampens cardiac hypertrophy. We have compared the effect of isoproterenol (ISO) and transverse aortic constriction (TAC) on hypertrophy in WT [control (CTR)] mice, total cGKI-KO mice, and cGKIβ rescue mice (βRM) lacking cGKI specifically in cardiomyocy...

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Autors principals: Lukowski, Robert, Rybalkin, Sergei D., Loga, Florian, Leiss, Veronika, Beavo, Joseph A., Hofmann, Franz
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851748/
https://ncbi.nlm.nih.gov/pubmed/20212138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001360107
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