Role of Phosphatidylinositol(4,5)bisphosphate Organization in Membrane Transport by the Unc104 Kinesin Motor

Unc104 (KIF1A) kinesin transports membrane vesicles along microtubules in lower and higher eukaryotes. Using an in vitro motility assay, we show that Unc104 uses a lipid binding pleckstrin homology (PH) domain to dock onto membrane cargo. Through its PH domain, Unc104 can transport phosphatidylinosi...

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Main Authors: Klopfenstein, Dieter R., Tomishige, Michio, Stuurman, Nico, Vale, Ronald D.
Formato: Artigo
Idioma:Inglês
Publicado: 2002
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851634/
https://ncbi.nlm.nih.gov/pubmed/12015984
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