Low Tissue Inhibitor of Metalloproteinases 3 and High Matrix Metalloproteinase 14 Levels Defines a Subpopulation of Highly Invasive Foam-Cell Macrophages

OBJECTIVE: An excess of metalloproteinases (MMPs) over tissue inhibitors of metalloproteinases (TIMPs) may favor atherosclerotic plaque rupture. We compared TIMP levels in nonfoamy and foam-cell macrophages (FCM) generated in vivo. METHODS AND RESULTS: In vivo generated rabbit FCM exhibited 84% redu...

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Hlavní autoři: Johnson, Jason L., Sala-Newby, Graciela B., Ismail, Yasmin, Aguilera, Concepción M., Newby, Andrew C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851011/
https://ncbi.nlm.nih.gov/pubmed/18566294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.170548
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