Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability

LGI1 in humans is responsible for a predisposition to autosomal dominant partial epilepsy with auditory features (ADPEAF). However, mechanisms of how LGI1 mutations cause epilepsy remain unclear. We have used a mouse chromosome engineering strategy to create a null mutation for the gene ortholog enc...

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Bibliographic Details
Main Authors:	Yu, Y. Eugene, Wen, Lei, Silva, Jeane, Li, Zhongyou, Head, Karen, Sossey-Alaoui, Khalid, Pao, Annie, Mei, Lin, Cowell, John K.
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2010
Subjects:	Articles
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2850618/ https://ncbi.nlm.nih.gov/pubmed/20130004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq047
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Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability

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