Pro-Survival Role for Parkinson's Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic Neurons

The mechanisms underlying the selective death of substantia nigra (SN) neurons in Parkinson disease (PD) remain elusive. While inactivation of DJ-1, an oxidative stress suppressor, causes PD, animal models lacking DJ-1 show no overt dopaminergic (DA) neuron degeneration in the SN. Here, we show that...

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Autori principali: Aron, Liviu, Klein, Pontus, Pham, Thu-Trang, Kramer, Edgar R., Wurst, Wolfgang, Klein, Rüdiger
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850379/
https://ncbi.nlm.nih.gov/pubmed/20386724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000349
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