The Structures of T87I Phosphono-CheY and T87I/Y106W Phosphono-CheY Help to Explain Their Binding Affinities to the FliM and CheZ Peptides

CheY is a response regulator in bacterial chemotaxis. E. coli CheY mutants T87I and T87I/Y106W CheY are phosphorylatable on Asp57 but unable to generate clockwise rotation of the flagella. To understand this phenotype in terms of structure, stable analogs of the two CheY-P mutants were synthesized:...

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Bibliographic Details
Main Authors: McAdams, Kenneth, Casper, Eric S., Haas, R. Matthew, Santarsiero, Bernard D., Eggler, Aimee L., Mesecar, Andrew, Halkides, Christopher J.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850201/
https://ncbi.nlm.nih.gov/pubmed/18801331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.08.019
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