The Anti-Inflammatory Activity of HMGB1 A Box Is Enhanced When Fused with C-Terminal Acidic Tail

HMGB1, composed of the A box, B box, and C tail domains, is a critical proinflammatory cytokine involved in diverse inflammatory diseases. The B box mediates proinflammatory activity, while the A box alone acts as a specific antagonist of HMGB1. The C tail contributes to the spatial structure of A b...

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Bibliographic Details
Main Authors: Gong, Wei, Zheng, Yingru, Chao, Fan, Li, Yuan, Xu, Zhizhen, Huang, Gang, Gao, Xiang, Li, Song, He, Fengtian
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850157/
https://ncbi.nlm.nih.gov/pubmed/20379370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/915234
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