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A Concise Enantioselective Synthesis of (−)-Ranirestat

[Image: see text] A concise, enantioselective synthesis of the potent aldose reductase inhibitor ranirestat (1) is reported. The synthesis was accomplished employing inexpensive, commercially available starting materials. A palladium-catalyzed asymmetric allylic alkylation (Pd-AAA) of malonate 4 was...

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Bibliografische gegevens
Hoofdauteurs: Trost, Barry M., Osipov, Maksim, Dong, Guangbin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850125/
https://ncbi.nlm.nih.gov/pubmed/20148531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol100167w
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