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A Concise Enantioselective Synthesis of (−)-Ranirestat
[Image: see text] A concise, enantioselective synthesis of the potent aldose reductase inhibitor ranirestat (1) is reported. The synthesis was accomplished employing inexpensive, commercially available starting materials. A palladium-catalyzed asymmetric allylic alkylation (Pd-AAA) of malonate 4 was...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2850125/ https://ncbi.nlm.nih.gov/pubmed/20148531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol100167w |
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