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Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase
Prostacyclin is a potent mediator of vasodilation and anti-platelet aggregation. It is synthesized from prostaglandin H(2) by prostacyclin synthase (PGIS), a member of Family 8 in the cytochrome P450 superfamily. Unlike most P450s, which require exogenous reducing equivalents and an oxygen molecule...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2850101/ https://ncbi.nlm.nih.gov/pubmed/16406803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2005.11.007 |
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