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REACTION MECHANISMS OF 15-HYDROPEROXYEICOSATETRAENOIC ACID CATALYZED BY HUMAN PROSTACYCLIN AND THROMBOXANE SYNTHASES
Prostacyclin synthase (PGIS) and thromboxane synthase (TXAS) are atypical cytochrome P450s. They do not require NADPH or dioxygen for isomerization of prostaglandin H(2) (PGH(2)) to produce prostacyclin (PGI(2)) and thromboxane A(2) (TXA(2)). PGI(2) and TXA(2) have opposing actions on platelet aggre...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2041921/ https://ncbi.nlm.nih.gov/pubmed/17459323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.03.012 |
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