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REACTION MECHANISMS OF 15-HYDROPEROXYEICOSATETRAENOIC ACID CATALYZED BY HUMAN PROSTACYCLIN AND THROMBOXANE SYNTHASES

Prostacyclin synthase (PGIS) and thromboxane synthase (TXAS) are atypical cytochrome P450s. They do not require NADPH or dioxygen for isomerization of prostaglandin H(2) (PGH(2)) to produce prostacyclin (PGI(2)) and thromboxane A(2) (TXA(2)). PGI(2) and TXA(2) have opposing actions on platelet aggre...

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Detalhes bibliográficos
Main Authors: Yeh, Hui-Chun, Tsai, Ah-Lim, Wang, Lee-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2041921/
https://ncbi.nlm.nih.gov/pubmed/17459323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2007.03.012
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