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Antigenic Experience Dictates Functional Role of Glycogen Synthase Kinase-3 in Human CD4(+) T Cell Responses

Signals induced by the TCR and CD28 costimulatory pathway have been shown to lead to the inactivation of the constitutively active enzyme, glycogen synthase kinase-3 (GSK3), which has been implicated in the regulation of IL-2 and T cell proliferation. However, it is unknown whether GSK3 plays a simi...

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Autors principals: Garcia, Carlos A., Benakanakere, Manjunatha R., Alard, Pascale, Kosiewicz, Michelle M., Kinane, Denis F., Martin, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849970/
https://ncbi.nlm.nih.gov/pubmed/19050253
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