Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma

HOXA genes encode critical transcriptional regulators of embryonic development that have been implicated in cancer. In this study, we documented functional relevance and mechanism of activation of HOXA9 in glioblastoma (GBM), the most common malignant brain tumor. Expression of HOXA genes was invest...

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Autori principali: Costa, Bruno M., Smith, Justin S., Chen, Ying, Chen, Justin, Phillips, Heidi S., Aldape, Kenneth D., Zardo, Giuseppe, Nigro, Janice, James, C. David, Fridlyand, Jane, Reis, Rui M., Costello, Joseph F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849935/
https://ncbi.nlm.nih.gov/pubmed/20068170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2189
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