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Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and risk of colorectal adenoma

INTRODUCTION: Prostaglandins are important inflammatory mediators; PGE(2) is the predominant prostaglandin in colorectal neoplasia and affects colorectal carcinogenesis. Prostaglandins are metabolites of omega-6 and omega-3 polyunsaturated fatty acids; their biosynthesis is the primary target of non...

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Detalhes bibliográficos
Main Authors: Poole, Elizabeth M., Hsu, Li, Xiao, Liren, Kulmacz, Richard J., Carlson, Christopher S., Rabinovitch, Peter S., Makar, Karen W., Potter, John D., Ulrich, Cornelia M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849740/
https://ncbi.nlm.nih.gov/pubmed/20086108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-09-0869
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