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Downregulation of Kv4.2 channels mediated by NR2B-containing NMDA receptors in cultured hippocampal neurons

Somatodendritic Kv4.2 channels mediate transient A-type potassium currents (I(A)), and play critical roles in controlling neuronal excitability and modulating synaptic plasticity. Our studies have shown a NMDA receptor-dependent downregulation of Kv4.2 and I(A). NMDA receptors are heteromeric comple...

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Hlavní autoři: Lei, Zhigang, Deng, Ping, Li, Yan, Xu, Zao C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849736/
https://ncbi.nlm.nih.gov/pubmed/19857555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2009.10.041
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