Antitumor Agents. 272. Structure–Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogs

Neo-tanshinlactone (1) and its previously reported analogs, such as 2, are potent and selective in vitro anti-breast cancer agents. The synthetic pathway to 2 was optimized from seven to five steps, with a better overall yield. Structure–activity relationships studies on these compounds revealed som...

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Autors principals: Dong, Yizhou, Shi, Qian, Pai, Huei-Chen, Peng, Chieh-Yu, Pan, Shiow-Lin, Teng, Che-Ming, Nakagawa-Goto, Kyoko, Yu, Donglei, Liu, Yi-Nan, Wu, Pei-Chi, Bastow, Kenneth F., Morris-Natschke, Susan L., Brossi, Arnold, Lang, Jing-Yu, Hsu, Jennifer L., Hung, Mien-Chie, Lee, Eva Y.-H. P., Lee, Kuo-Hsiung
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849726/
https://ncbi.nlm.nih.gov/pubmed/20148565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1000858
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