The Nematode Eukaryotic Translation Initiation Factor 4E/G Complex Works with a trans-Spliced Leader Stem-Loop To Enable Efficient Translation of Trimethylguanosine-Capped RNAs

Eukaryotic mRNA translation begins with recruitment of the 40S ribosome complex to the mRNA 5′ end through the eIF4F initiation complex binding to the 5′ m(7)G-mRNA cap. Spliced leader (SL) RNA trans splicing adds a trimethylguanosine (TMG) cap and a sequence, the SL, to the 5′ end of mRNAs. Efficie...

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Main Authors: Wallace, Adam, Filbin, Megan E., Veo, Bethany, McFarland, Craig, Stepinski, Janusz, Jankowska-Anyszka, Marzena, Darzynkiewicz, Edward, Davis, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849463/
https://ncbi.nlm.nih.gov/pubmed/20154140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01437-09
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