Functional Characterization of an Extended Binding Component of the Actin-ADP-Ribosylating C2 Toxin Detected in Clostridium botulinum Strain (C) 2300

Clostridium botulinum C2 toxin consists of the binding component C2II and the enzyme component C2I, which ADP-ribosylates G-actin of eukaryotic cells. Trypsin-activated C2II (C2IIa) forms heptamers that mediate cell binding and translocation of C2I from acidic endosomes into the cytosol of target ce...

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Hlavní autoři: Sterthoff, Charlott, Lang, Alexander E., Schwan, Carsten, Tauch, Andreas, Aktories, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Molecular Pathogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849413/
https://ncbi.nlm.nih.gov/pubmed/20145093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01351-09
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