Production of a Class II Two-Component Lantibiotic of Streptococcus pneumoniae Using the Class I Nisin Synthetic Machinery and Leader Sequence

Recent studies showed that the nisin modification machinery can successfully dehydrate serines and threonines and introduce lanthionine rings in small peptides that are fused to the nisin leader sequence. This opens up exciting possibilities to produce and engineer larger antimicrobial peptides in v...

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Détails bibliographiques
Auteurs principaux: Majchrzykiewicz, Joanna A., Lubelski, Jacek, Moll, Gert N., Kuipers, Anneke, Bijlsma, Jetta J. E., Kuipers, Oscar P., Rink, Rick
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Chemistry; Biosynthesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849381/
https://ncbi.nlm.nih.gov/pubmed/20100873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00883-09
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