Production of a Class II Two-Component Lantibiotic of Streptococcus pneumoniae Using the Class I Nisin Synthetic Machinery and Leader Sequence

Recent studies showed that the nisin modification machinery can successfully dehydrate serines and threonines and introduce lanthionine rings in small peptides that are fused to the nisin leader sequence. This opens up exciting possibilities to produce and engineer larger antimicrobial peptides in v...

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Detalhes bibliográficos
Main Authors: Majchrzykiewicz, Joanna A., Lubelski, Jacek, Moll, Gert N., Kuipers, Anneke, Bijlsma, Jetta J. E., Kuipers, Oscar P., Rink, Rick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Chemistry; Biosynthesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849381/
https://ncbi.nlm.nih.gov/pubmed/20100873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00883-09
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