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Fasting Increases Tobramycin Oral Absorption in Mice

The pharmacokinetics of the aminoglycoside tobramycin was evaluated after oral administration to fed or fasting (15 h) mice. As expected, under normal feeding conditions, oral absorption was negligible; however, fasting induced a dramatic increase in tobramycin bioavailability. The dual-sugar test w...

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Detalhes bibliográficos
Main Authors: De Leo, Luigina, Di Toro, Nicola, Decorti, Giuliana, Malusà, Noelia, Ventura, Alessandro, Not, Tarcisio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849372/
https://ncbi.nlm.nih.gov/pubmed/20086144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01172-09
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