Activity of Linezolid in an In Vitro Pharmacokinetic-Pharmacodynamic Model Using Different Dosages and Staphylococcus aureus and Enterococcus faecalis Strains with and without a Hypermutator Phenotype

The influence of antibiotic dosages and bacterial mutator phenotypes on the emergence of linezolid-resistant mutants was evaluated in an in vitro pharmacokinetic-pharmacodynamic model. A twice-daily 0.5-h infusion of a 200-, 600-, or 800-mg dose for 48 h was simulated against four strains (MIC, 2 μg...

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Detalhes bibliográficos
Main Authors: Ba, Boubakar B., Arpin, Corinne, Bikie Bi Nso, Branly, Dubois, Véronique, Saux, Marie-Claude, Quentin, Claudine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849367/
https://ncbi.nlm.nih.gov/pubmed/20100878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01022-09
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