Cyclin D1 splice variants: polymorphism, risk, and isoform specific regulation in prostate cancer

PURPOSE: Alternative CCND1 splicing results in cyclin D1b, which has specialized, pro-tumorigenic functions in prostate not shared by the cyclin D1a (full-length) isoform. Here, the frequency, tumor relevance, and mechanisms controlling cyclin D1b were challenged. EXPERIMENTAL DESIGN: First, relativ...

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Autori principali: Comstock, Clay E.S., Augello, Michael A., Benito, Ruth Pe, Karch, Jason, Tran, Thai H., Utama, Fransiscus E., Tindall, Elizabeth A., Wang, Ying, Burd, Craig J., Groh, Eric M., Hoang, Hoa N., Giles, Graham G., Severi, Gianluca, Hayes, Vanessa M., Henderson, Brian E., Marchand, Loic Le, Kolonel, Laurence N., Haiman, Christopher A., Baffa, Raffaele, Gomella, Leonard G., Knudsen, Erik S., Rui, Hallgeir, Henshall, Susan M., Sutherland, Robert L., Knudsen, Karen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849314/
https://ncbi.nlm.nih.gov/pubmed/19706803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2865
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