IL-12 induces salivary gland dysfunction, providing a new mouse model of Sjögren's syndrome

OBJECTIVE: Interleukin-12 (IL-12) is a pleiotropic cytokine and is elevated in affected organs of Sjögren's syndrome (SS) patients. We have previously reported in CBA mice that over-expression of IL-12 leads to mononuclear infiltration of salivary and lacrimal glands, as well as expansion of br...

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Main Authors: Vosters, Jelle L., Landek-Salgado, Melissa A., Yin, Hongen, Swaim, William D., Kimura, Hiroaki, Tak, Paul P., Caturegli, Patrizio, Chiorini, John A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849131/
https://ncbi.nlm.nih.gov/pubmed/19950301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24980
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