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A Wnt Oscillator Model for Somitogenesis
We propose a model for the segmentation clock in vertebrate somitogenesis, based on the Wnt signaling pathway. The core of the model is a negative feedback loop centered around the Axin2 protein. Axin2 is activated by β-catenin, which in turn is degraded by a complex of GSK3β and Axin2. The model pr...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849083/ https://ncbi.nlm.nih.gov/pubmed/20303851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.11.039 |
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