Reciprocal regulation of activating and inhibitory Fcγ receptors by TLR7/8 activation: Implications for tumor immunotherapy

PURPOSE: Activation of Toll-like Receptors (TLR) 7 and 8 by engineered agonists has been shown to aid in combating viruses and tumors. Here, we wished to test the effect of TLR7/8 activation on monocyte Fcγ receptor (FcγR) function, as they are critical mediators of antibody therapy. EXPERIMENTAL DE...

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Autors principals: Butchar, Jonathan P., Mehta, Payal, Justiniano, Steven E., Guenterberg, Kristan D., Kondadasula, Sri-Vidya, Mo, Xiaokui, Chemudupati, Mahesh, Kanneganti, Thirumala-Devi, Amer, Amal, Muthusamy, Natarajan, Jarjoura, David, Marsh, Clay B., Carson, William E., Byrd, John C., Tridandapani, Susheela
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848878/
https://ncbi.nlm.nih.gov/pubmed/20332325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2591
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