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Disorder, promiscuity, and toxic partnerships
Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2848715/ https://ncbi.nlm.nih.gov/pubmed/19596229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.06.024 |
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