A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice

BACKGROUND: Metabolites of arachidonic acid such as prostacyclin (PGI(2)) have been shown to participate in the pathogenesis of pulmonary fibrosis by inhibiting the expression of pro-inflammatory and pro-fibrotic mediators. In this investigation, we examined whether iloprost, a stable PGI(2 )analogu...

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Autores principales: Zhu, Yuanjue, Liu, Yong, Zhou, Weixun, Xiang, Ruolan, Jiang, Lei, Huang, Kewu, Xiao, Yu, Guo, Zijian, Gao, Jinming
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848635/
https://ncbi.nlm.nih.gov/pubmed/20302663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-11-34
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