The Fischer 344 Rat Reflects Human Susceptibility to Francisella Pulmonary Challenge and Provides a New Platform for Virulence and Protection Studies

BACKGROUND: The pathogenesis of Francisella tularensis, the causative agent of tularemia, has been primarily characterized in mice. However, the high degree of sensitivity of mice to bacterial challenge, especially with the human virulent strains of F. tularensis, limits this animal model for screen...

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Detalhes bibliográficos
Main Authors: Ray, Heather J., Chu, Ping, Wu, Terry H., Lyons, C. Rick, Murthy, Ashlesh K., Guentzel, M. Neal, Klose, Karl E., Arulanandam, Bernard P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848594/
https://ncbi.nlm.nih.gov/pubmed/20376351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009952
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