Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

BACKGROUND: Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain uncharacterized, particularly in the context of human diseases such as cancer. We investigated the role of KDM5B, a JmjC histone demethyla...

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Detalhes bibliográficos
Main Authors: Hayami, Shinya, Yoshimatsu, Masanori, Veerakumarasivam, Abhimanyu, Unoki, Motoko, Iwai, Yukiko, Tsunoda, Tatsuhiko, Field, Helen I, Kelly, John D, Neal, David E, Yamaue, Hiroki, Ponder, Bruce AJ, Nakamura, Yusuke, Hamamoto, Ryuji
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848192/
https://ncbi.nlm.nih.gov/pubmed/20226085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-59
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