GCN5-dependent acetylation of HIV-1 integrase enhances viral integration

BACKGROUND: An essential event during the replication cycle of HIV-1 is the integration of the reverse transcribed viral DNA into the host cellular genome. Our former report revealed that HIV-1 integrase (IN), the enzyme that catalyzes the integration reaction, is positively regulated by acetylation...

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Main Authors: Terreni, Mariaelena, Valentini, Paola, Liverani, Vania, Gutierrez, Maria Ines, Di Primio, Cristina, Di Fenza, Armida, Tozzini, Valentina, Allouch, Awatef, Albanese, Alberto, Giacca, Mauro, Cereseto, Anna
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848186/
https://ncbi.nlm.nih.gov/pubmed/20226045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-7-18
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