Senescent Fibroblasts Promote Neoplastic Transformation of Partially Transformed Ovarian Epithelial Cells in a Three-dimensional Model of Early Stage Ovarian Cancer

Most epithelial ovarian cancers are diagnosed postmenopausally, although the well-established epidemiological risk factors (parity, oral contraceptive use) are premenopausal. We hypothesized that accumulation of senescent fibroblasts, together with concomitant loss of presenescent fibroblasts within...

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Bibliographic Details
Main Authors: Lawrenson, Kate, Grun, Barbara, Benjamin, Elizabeth, Jacobs, Ian J, Dafou, Dimitra, Gayther, Simon A
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847739/
https://ncbi.nlm.nih.gov/pubmed/20360942
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