Senescent Fibroblasts Promote Neoplastic Transformation of Partially Transformed Ovarian Epithelial Cells in a Three-dimensional Model of Early Stage Ovarian Cancer

Most epithelial ovarian cancers are diagnosed postmenopausally, although the well-established epidemiological risk factors (parity, oral contraceptive use) are premenopausal. We hypothesized that accumulation of senescent fibroblasts, together with concomitant loss of presenescent fibroblasts within...

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Detaylı Bibliyografya
Asıl Yazarlar: Lawrenson, Kate, Grun, Barbara, Benjamin, Elizabeth, Jacobs, Ian J, Dafou, Dimitra, Gayther, Simon A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press Inc. 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847739/
https://ncbi.nlm.nih.gov/pubmed/20360942
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