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Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence

The cellular mechanisms underlying pathological alcohol seeking remain poorly understood. Here, we show an enhancement of nucleus accumbens (NAcb) core action potential firing ex vivo after protracted abstinence from alcohol but not sucrose self-administration. Increased firing is associated with re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hopf, F. Woodward, Bowers, M. Scott, Chang, Shao-Ju, Chen, Billy T., Martin, Miguel, Seif, Taban, Cho, Saemi L., Tye, Kay, Bonci, Antonello
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847608/
https://ncbi.nlm.nih.gov/pubmed/20223203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.02.015
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