Sensitive digital quantification of DNA methylation in clinical samples

Abnormally methylated genes are increasingly being used as cancer biomarkers 1, 2. For clinical applications, it is important to precisely determine the number of methylated molecules in the analyzed sample. We here describe a digital approach that can enumerate one methylated molecule out of ~5000...

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Detalhes bibliográficos
Main Authors: Li, Meng, Chen, Wei-dong, Papadopoulos, Nickolas, Goodman, Steven, Bjerregaard, Niels Christian, Laurberg, Søren, Levin, Bernard, Juhl, Hartmut, Arber, Nadir, Moinova, Helen, Durkee, Kris, Schmidt, Kerstin, He, Yiping, Diehl, Frank, Velculescu, Victor E, Zhou, Shibin, Diaz, Luis A, Kinzler, Kenneth W, Markowitz, Sanford D, Vogelstein, Bert
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847606/
https://ncbi.nlm.nih.gov/pubmed/19684580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1559
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