Activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine against human cytomegalovirus when administered as single-bolus dose and continuous infusion in in vitro cell culture perfusion system.

HPMPC [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine] is a potent inhibitor of human cytomegalovirus (HCMV) replication as determined by conventional tissue culture methods in which the drug concentration remains constant over time. Previous studies have shown HPMPC to have a long intracellula...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Moore, M R, Hamzeh, F M, Lee, F E, Lietman, P S
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284752/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7840578/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.10.2404
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