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Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice.

The phosphonylmethoxyalkyl derivative (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) was evaluated for its in vivo efficacy in several model infections for herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and thymidine kinase-deficient (TK-) HSV-1 in mice. In hairless mice infecte...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: De Clercq, E, Holý, A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245082/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2069375/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.4.701
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