1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo.

1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosi ne (cyclic [cHPMPC]) was evaluated as a novel antiviral agent in comparison with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC). Evaluation for in vitro activity against herpes simplex virus type 2 in MA-104 and MRC-5 ce...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Bischofberger, N, Hitchcock, M J, Chen, M S, Barkhimer, D B, Cundy, K C, Kent, K M, Lacy, S A, Lee, W A, Li, Z H, Mendel, D B
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 1994
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284749/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7840575/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.10.2387
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