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Effect of threonine-to-methionine substitution at position 265 on structure and function of TEM-1 beta-lactamase.

TEM beta-lactamase variants with the amino acid substitutions R164S, E104K, G238S, and E240K (ABL numbering) display increased activity toward extended-spectrum cephalosporins. The T265M substitution is frequently found to be associated with the above substitutions in extended-spectrum beta-lactamas...

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Detalles Bibliográficos
Main Authors: Huang, W, Le, Q Q, LaRocco, M, Palzkill, T
Formato: Artigo
Idioma:Inglês
Publicado: 1994
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC284728/
https://ncbi.nlm.nih.gov/pubmed/7840555
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