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Effect of threonine-to-methionine substitution at position 265 on structure and function of TEM-1 beta-lactamase.
TEM beta-lactamase variants with the amino acid substitutions R164S, E104K, G238S, and E240K (ABL numbering) display increased activity toward extended-spectrum cephalosporins. The T265M substitution is frequently found to be associated with the above substitutions in extended-spectrum beta-lactamas...
Guardat en:
| Publicat a: | Antimicrob Agents Chemother |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1994
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284728/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7840555/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.10.2266 |
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