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Heat Shock Protein gp96 Is a Master Chaperone for Toll-like Receptors and Is Important in the Innate Function of Macrophages

gp96 is an endoplasmic reticulum chaperone for cell-surface Toll-like receptors (TLRs). Little is known about its roles in chaperoning other TLRs or in the biology of macrophage in vivo. We generated a macrophage-specific gp96-deficient mouse. Despite normal development and activation by interferon-...

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Detalhes bibliográficos
Main Authors: Yang, Yi, Liu, Bei, Dai, Jie, Srivastava, Pramod K., Zammit, David J., Lefrançois, Leo, Li, Zihai
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847270/
https://ncbi.nlm.nih.gov/pubmed/17275357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2006.12.005
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